PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhancedin VivoEfficacy
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چکیده
منابع مشابه
PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
A major limitation of biopharmaceutical proteins is their fast clearance from circulation via kidney filtration, which strongly hampers efficacy both in animal studies and in human therapy. We have developed conformationally disordered polypeptide chains with expanded hydrodynamic volume comprising the small residues Pro, Ala and Ser (PAS). PAS sequences are hydrophilic, uncharged biological po...
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Coagulation factors VII (FVII), IX (FIX), X (FX), and protein C share the same domain organization but display very different plasma half-lives. It is plausible that the half-life is influenced by the activation peptide, differing in length and glycosylation and missing in FVII. To test this hypothesis, the influence of activation peptides on the plasma half-life of human FVII was studied by ad...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2015
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp5007147